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Published Resources Details Journal Article

Kamboh, M. I., KirK, R. L., & Clark, P.
Alpha-1-antitrypsin (PI) types in Asian, Pacific and Aboriginal Australian populations
Disease Markers
vol. 1, 1983, pp. 33-42

Isoelectric focusing in thin-layer polyacrylamide gels has been used to examine the phenotypes of alpha-1-antitrypsin (PI) in 5444 individuals from Asian, Pacific and Australian Aboriginal populations. A marked variation was observed in the distribution of PI M subtypes in different ethnic groups. The highest frequencies of PI*M2 alleles were observed in the Papua New Guinea Highlands (67 percent) and Australian Aboriginal populations (62 percent). High frequencies of P1*M2 alleles were found also in lowland Papua New Guineans, most Indonesian populations as well as Fiji and Nauru and were significantly lower in other Asian and Pacific Island populations (12-25 percent). Indian samples are characterized by having high frequencies (up to 20 percent) of the PI*M3 allele, whereas other populations showed low frequencies of this allele varying from 1 to 11 percent. No examples of the deficient Z phenotypes were observed. However, a new non-deficient allele. PIIndonesia, was detected at polymorphic frequencies in three Indonesian populations. The PI*S allele was present sporadically in Indonesia, Pacific and central Australian Aboriginal populations.

Accession: 004700234


Related Archival resources


  • Reprints, 1958 - 1990, PUB-020; National Centre for Indigenous Genomics. Details