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Published Resources Details Journal Article

Kamboh, M. I., & Kirwood, C.
Genetic polymorphism of thyroxin-binding globulin (TBG) in the Pacific area
American Journal of Human Genetics
vol. 36, no. 3, 1984, pp. 646-654

Human plasma samples, radiolabeled with [125I]thyroxin, from the Asian, Pacific, and Australian area have been subjected to isoelectric focusing to reveal genetic variation in thyroxin-binding globulin (TBG). A genetically determined electrophoretic slow variant, TBG S, indistinguishable from the variant found in black Africans, has been observed with a frequency of 1%-10% in all Melanesian and Polynesian populations studied. The TBG S variant is present also with low frequency in Micronesians and in some Indonesian populations. However, East Asians, Indians, and Australian Aborigines were found to be monomorphic.

PMCID: PMC1684445

Related Archival resources


  • Reprints, 1958 - 1990, PUB-020; National Centre for Indigenous Genomics. Details